Tumor‐infiltrating immune cells, such as CD8+ T cells, NK cells, and macrophages, populate in the GISTs, with the key role in tumor surveillance.30 In addition, these immune cells also contribute to the antitumor effects of RTK‐targeted therapy.31, 32 Immune microenvironment is a vital part of GIST microenvironment. Here, CD8A is linked to gastrointestinal stromal tumor.