Naturally, tumor cells will develop some mechanisms for confronting the strikes from the antitumor immune system, known as the canonical checkpoint regulating sites‐programed death 1 (PD1)/programed death ligand 1 (PD‐L1) axis and cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4) modulator.32, 33 Intriguingly, DKK family is also closely related to immune response and has the ability to block antitumor immune cell activation, mediating the tumor‐promoting mechanism.34 This evidence concerns the gene CTLA4 and neoplasm.