Overexpression of DKK4 slightly abolished the malignancy of GIST‐430 cells, which is supposed to be that, redundant DKK4 in vitro could only target the tumor cells to inhibit their Wnt signaling, without an integrated coping mechanism for DKK4 accumulation and other TME stromal cells existing. This evidence concerns the gene DKK4 and gastrointestinal stromal tumor.