On the other hand, we speculate that DKK4 should be transcriptionally upregulated by activated Wnt pathway and serve as an effector of activated Wnt signaling driving malignancy in high‐risk GIST, owing to the facts from GSEA analysis, TFs prediction, IHC analysis, and previous studies (Figure 4). This evidence concerns the gene DKK4 and gastrointestinal stromal tumor.