CD274 and neoplasm: Naturally, tumor cells will develop some mechanisms for confronting the strikes from the antitumor immune system, known as the canonical checkpoint regulating sites‐programed death 1 (PD1)/programed death ligand 1 (PD‐L1) axis and cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4) modulator.32, 33 Intriguingly, DKK family is also closely related to immune response and has the ability to block antitumor immune cell activation, mediating the tumor‐promoting mechanism.34