To explore distinct tumor biomarkers, well indicating the risk of GIST patients, we compared the expression profiles of freshly excised tumor tissues from four high‐risk and four low‐risk GISTs, stratified by modified National Institute of Health (NIH) consensus criteria.36, 37 Among those significantly upregulated genes (P < .05 and fold change > 4) in high‐risk samples, DKK4, as a canonical Wnt signaling inhibitor‐coding gene, came into our sights (Figure 1A). The gene discussed is DKK4; the disease is gastrointestinal stromal tumor.