NQO1 and cancer: Many studies have reported that β‐lap induces an undesired futile redox cycle, which is dependent on NQO1, resulting in an imbalance of redox cycle and induces oxidative stress to DNA by intracellular ROS production, which sequentially leads to PARP activation in cancer cells (Reinicke et al., 2005; Morales et al. 2014).