Indeed, the prevalence of BRAF mutations was recently reported to be as high as 21% in CRC patients in a Norwegian registry.10 The overwhelming majority (> 95%) of BRAF mutations in mCRC occur in codon 600, involving a T1799A transversion in exon 15, which results in the substitution of a valine amino acid for a glutamic acid (V600E mutation). This evidence concerns the gene BRAF and colorectal carcinoma.