ZnO specific gene signature further englobed the overexpression of Pla2g16 (FC + 7) a membrane damage sensor; S100a4 (FC + 7) involved in macrophage-induced lung fibrosis (Li et al. 2018; Zhang et al. 2018); Rps14 (FC + 6), Rps27 (FC + 5), and Mrps15 (FC + 5), three protein synthesis regulators. Here, RPS27 is linked to pulmonary fibrosis.