Recently study reported that SYP is hypermethylated and decreased in human Alzheimer’s Disease brain tissue [21–23]; therefore, we hypothesised that the upregulation of SYP in CPAs is correlated with the promoter of methylation of SYP. We applied methylation PCR assay to detect the methylation status of SYP in CPA samples and the control samples. Here, SYP is linked to early-onset autosomal dominant Alzheimer disease.