Moreover, together with our previous findings of lower serum Lipid 654 levels in MS patients [16], TLR2 tolerance-induced attenuation of EAE [10], and enhanced TLR2 responsiveness among MS patients [17], the present results represent further proof-of-concept evidence that inducing TLR2 tolerance in vivo mediates functional changes in TLR2 signaling that has physiologic and disease-relevant effects. This evidence concerns the gene TLR2 and myeloid sarcoma.