In contrast, some genes involved in inhibiting growth or mutations in genes result in short stature (e.g., dwarfism), including aggrecan (ACAN), obscurin-like 1 (OBSL1), growth factor receptor-bound protein 10 (GRB10), pituitary specific transcription factor 1 (PIT-1), Kir inward rectifier potassium channels (KCNJ2), Noggin (NOG), cyclin-dependent kinase inhibitor 1B (CDKN1B), and glypican-3 (GPC3), which have been called “short stature-related genes”. This evidence concerns the gene ACAN and Severe short stature.