Interestingly, evidence of positive selection was also determined in the lineage leading to the largest toothed whale, i.e., the sperm whale (20.5 m in length and 57,000 kg in mass) in the PLOD1 gene, which has been previously shown to cause the Nevo syndrome, clinically characterized by increased growth, kyphosis, a prominent forehead, and other factors [29]. This evidence concerns the gene PLOD1 and Ehlers-Danlos syndrome, kyphoscoliotic type 1.