To investigate the influence of elevated TFPI and thrombomodulin in Bambi‐deficient mice upon fibrin accumulation and thrombus stability in vivo, we performed the laser‐induced thrombosis model under conditions where each endogenous anticoagulant protein was blocked using inhibitory polyclonal antithrombomodulin and anti‐TFPI antibodies. The gene discussed is THBD; the disease is deep vein thrombosis.