Juretic et al., (2012) conducted a study to determine the salivary concentrations of TNF-α in patients with premalignant lesions (PML) and malignant lesions using ELISA and observed that the mean values of TNF-α are greater in OSCC (0.739 ± 0.176) than PML (0.601 ± 0.178) and controls (0.013 ± 0.033) (Juretic et al., 2012). Here, TNF is linked to cancer.