However this finding was in the line with another case report concerning a hepatocellular carcinoma patient who had extreme thrombocytosis with a low vWF:RCo but high vWF:Ag resulting from antibodies that interfere with the binding of vWF to platelets without causing clearance of the vWF antigen (Chen et al., 2005). The gene discussed is VWF; the disease is Thrombocytosis.