Thus, cancer-associated SPOP mutations compromise its substrate recognition and the degradation of an increasing number of known and potential oncoproteins such as DAXX (18,181,182), BRD4 (189,190), MYC (191), the androgen receptor (AR) (192), PD-L1 (193), ERG (194) and Nanog (195,196). Here, DAXX is linked to cancer.