APOA5 is a ‘well-known’ CAD-associated locus (e.g. rs964184; CARDIoGRAM Consortium et al., 2011), thus the rs662799 CAD association detected in this RE2C analysis represents a confident positive assignment that can guide future functional genomic experiments to identify the underlying causal variants(s). This evidence concerns the gene APOA5 and coronary artery disorder.