In 4S, simvastatin reduced incident HF by 19% [41], whilst in the post-ACS studies (PROVE IT-TIMI 22), intensive statin therapy reduced the rate of hospitalization for HF (especially if subjects had elevated baseline B-type natriuretic peptide (BNP)) [39], and in the TNT trial in patients with stable CAD, hospitalization for HF was lower in the intensive statin treatment arm [43]. Here, NPPB is linked to hydrops fetalis.