SLC6A4 and major depressive disorder: MiR-16 is a miRNA that has been widely implicated in the pathophysiology of depression; for examples, Baudry and colleagues demonstrated that the serotonin transporter (SERT) expression, a well-known vulnerability gene for depression, is modulated by miR-16 in 1C11 neuroectodermal cell line (Baudry et al. 2010).