AGO1 and major depressive disorder: Indeed, they investigated single-nuclear polymorphisms (SNPs) within a wide panel of genes including DiGeorge syndrome chromosomal region 8 (DGCR8), Argonaute1 (AGO1), and Gem-Associated Protein4 in 314 depressed patients and 252 healthy controls, showing that SNPs within DGCR8 (rs3757) and AGO1 (rs636832) are associated with an increased risk for depression (He et al. 2012).