MC4R and obesity due to melanocortin 4 receptor deficiency: Also, the study of Lazopoulou et al. 26 proved that BW and BMI were associated with the C allele of MC4R rs17782313, while Garcia-Solis et al. 25 established a significant correlation between heterozygous MC4R rs17782313 carriers and both blood pressure and obesity risk in Mexican school-aged children25.