In liver cancer cell lines (HepG2 and Hep3B), MALAT-1 regulates cancer-related microRNAs (miRNAs), such as mir-574 and mir-20b, contributing to potential targets (such as RAS and MAPK) and Wnt/β-catenin signaling pathway, thus promoting HCC development16. The gene discussed is MALAT1; the disease is hepatocellular carcinoma.