CD8A and neoplasm: Here the authors show that Nrp-1 is co-expressed with PD-1 on a subset of CD8 tumour-infiltrating T lymphocytes and inhibits T-cell migration and cytotoxicity when bound by its ligand semaphorin-3A, while blockade of Nrp-1 synergises with anti-PD-1 to promote antitumour immunity in mouse tumour models.