SETD2 and enteropathy-associated T-cell lymphoma: SETD2 is the sole trimethyltransferase responsible for H3K36me3 and is frequently mutated in various types of malignancies in lymphoid cell lineages, including acute lymphoblastic leukemia23,24, enteropathy-associated T cell lymphoma (EATL), and hepatosplenic T cell lymphoma (HSTL)25,26.