After eliminating the published polymorphisms in the dbSNP database and the 1000 Genomes human genome polymorphism data set (1000G)34, we removed variants with a minor allele frequency (MAF) of >0.01 and identified 2 missense SETD2 mutations in PID patents who did not carry previously reported PID-associated genetic alterations35 (Supplementary Table 6 and Supplementary Fig. 9a). The gene discussed is SETD2; the disease is pelvic inflammatory disease.