MYC and cancer: Moreover, the MycER chimeric protein system, which can be applied to cell-line and mouse models of many cancer types, has been used for studies of MYC in the cell cycle, genomic instability, transformation and synthetic lethal interactions (Eilers et al., 1989; Felsher and Bishop, 1999; Kessler et al., 2012; Liu et al., 2012; Pelengaris et al., 1999, 2001, 2004).