NFI factors and AR have been shown to co-regulate known ARTGs such as PSA and FKBP5 in prostate cancer cell lines (Grabowska et al., 2014, 2016) and could play a role here in regulating organ development (Campbell et al., 2008; Gründer et al., 2002; Messina et al., 2010; Murtagh et al., 2003; Steele-Perkins et al., 2005). This evidence concerns the gene FKBP5 and Familial prostate cancer.