Inhibition of RIPK2 with the tyrosine kinase inhibitor gefitinib (Tigno-Aranjuez et al, 2010, 2014) and the RIPK2-specific compound GSK583 (Haile et al, 2016) also led to spontaneous induction of RIPosomes independent of infection (Fig S7A). Here, RIPK2 is linked to infection.