Albeit overexpression of RIPK2 led to some NF-κB activation and induction of IL-8 (McCarthy et al, 1998), the inflammatory response 6 h post infection (p.i.)was much higher, also in cells induced for EGFP-RIPK2 expression for 16 h, compared with noninduced cells (Fig 1B). This evidence concerns the gene CXCL8 and infection.