CCN2 and hepatocellular carcinoma: (A) SMMC-7721 and HCC-LM3 cells were treated with different amounts of TGF-β1 (approximately 0–20 ng/ml) for 2 h followed by qRT-PCR was used to detect the expression of IL-11 and CTGF; (B) IL-11 and CTGF expression was examined by qRT-PCR following treatment with 10 ng/ml TGF-β1 for the various time periods (0, 1, 2, 4, 6, 8, 12, and 24 h).