The multivariate logistic regression analysis showed that the independent factors associated with PAD in patients on HD were a higher CRP level (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.00–1.06; p = 0.030), vascular access provided by a Hickman catheter (OR, 4.66; 95% CI, 1.03–21.0; p = 0.045), and presence of PAD symptoms based on the Fontaine classification (OR, 5.20; 95% CI, 2.60–10.4; p < 0.001). This evidence concerns the gene CRP and peripheral arterial disease.