Moreover, A. Togashi et al. reported that hypoxia-inducible protein-2 (HIG2) binding to FZD10 enhanced oncogenic Wnt signaling and its own transcription, thus suggesting that HIG2-FZD10 interaction and activation of the Wnt signaling pathway are both involved in development and progression of renal cell carcinoma [40]. Here, FZD10 is linked to hereditary clear cell renal cell carcinoma.