PG2-induced alteration in patients’ sera cytokine profile determined using the Cytokine Human Magnetic 30-Plex Panel for the LuminexTM platform and Luminex®100/200TM system revealed that compared to the baseline sera cytokine levels, PG2 induced significant reduction in the production of inflammatory cytokines IL-1β (p = 0.014), IL-4 (p = 0.04), IL-6 (p = 0.012), IL-10 (p = 0.019), IL-12 (p = 0.03), IL-13 (p = 0.025), IL-17 (p = 0.018), TGF-β1 (p = 0.024), IFN-γ (p = 0.031), GM-CSF (p = 0.014), VEGF (p = 0.023), and chemokine MCP1 (p = 0.017) in our metastatic disease cohort. This evidence concerns the gene CSF2 and metastatic neoplasm.