SOCS1 and renal fibrosis: Furthermore, three miRNAs have been associated with renal fibrosis in LN patients: miR-410, which contributes to renal fibrosis by inhibiting interleukin-6 [24], miR-29c as predictor of early renal fibrosis [25], and miR-150, which promotes renal fibrosis by downregulation of SOCS1 [26].