In contrast, the dipeptidyl peptidase-4 inhibitor (DPP-4), vildagliptin, known to block the degradation of the incretin hormones GLP-1 and GIP, did not attenuate the fall in SBP and DBP during ID glucose administration compared with placebo in T2DM [88]. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.