A hallmark study by Pikarsky et al. showed that in Mdr2 knockout mouse, which spontaneously develop hepatitis and liver cancer, inhibition of NF-κB signaling by overexpression of the hepatocyte-specific inducible IκB-super-repressor (non-degradable mutant form of IκBα) leads to inhibition of tumorigenesis [63]. This evidence concerns the gene NFKB1 and liver cancer.