Weeks et al. detected 101 differentially expressed proteins between PDAC and PC patients by MALDI-TOF MS, highlighting CD59 glycoprotein (CD59), annexin A2 (ANXA2), 21 kDa gelsolin (GSN) fragment, protein S100-A9 (S100A9) and tumor necrosis factor alpha-induced protein 3 (TNFAIP3), which have been found to be overexpressed in PDAC tissues [21]. Here, ANXA2 is linked to pachyonychia congenita.