Combining the latter finding with our RNA-Seq data, which indicate that the blockade of PD-L1 upregulates genes associated with DNA repair, such as MEN1 [29] and RNASEH1 [30], suggests the involvement of atezolizumab in regulating DNA damage response/genomic instability and telomere integrity in cancer cells. The gene discussed is RNASEH1; the disease is cancer.