MMP2 and hypertensive disorder: They also decrease redox-sensitive gene activation, preventing the expression of two major pro-angiogenic factors (vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2)) in smooth muscle cells, increase the production of major vasodilatory factors (NO, endothelium-derived hyperpolarizing factor (EDHF) as well as prostacyclin), inhibit angiogenesis (cell migration and proliferation of blood vessels), and also reduce platelet aggregation and hypertension [105,106,107,108,109,110].