Figure 2A presents the average RES scores of several pathways analyzed in each of the four regions profiled from the CCRCC samples. The averages were determined for 107 APO, 37 BTF, 131 CSP, 91 CCY, 100 OXP, 54 RCC and 31 RPO genes out of the 12610 distinct genes whose expression was adequately quantified in all four regions of the CCRCC samples. WPR analysis of the CCRCC samples for the same pathways returned the results from Figure 2B. Note that (by far) the most affected pathway was (as expected) RCC (the renal cell carcinoma) followed by OXP (oxidative phosphorylation). The gene discussed is AOPEP; the disease is hereditary clear cell renal cell carcinoma.