On the other hand, in a clinical setting, Yagishita et al. [13] retrospectively analyzed the outcomes of non-squamous NSCLC patients, and showed that the frequency of local relapse after chemo-radiation therapy was significantly lower in patients with EGFR mutations than in those with wild-type EGFR (4% versus 21%). Here, EGFR is linked to non-small cell lung carcinoma.