Evidences have been presented that hyperactive nuclear AKT is involved in tumorigenesis by promoting proliferation and maintenance of stemness in cancer stem cells by phosphorylation and inactivation of the cell cycle inhibitory protein CDKN1A (Jain et al., 2015), as well as by its antiapoptotic effect (Lee et al., 2008, Rubio et al., 2009). The gene discussed is AKT1; the disease is cancer.