Although it remains elusive how AKT is activated within the nucleus (Ananthanarayanan et al., 2005, Andjelkovic et al., 1997, Liu and Brown, 2011), activated nuclear AKT is reported in various cancers such as lung, breast, and prostate cancers as well as in acute myeloid leukemia (Cappellini et al., 2003, Lee et al., 2002, Nicholson et al., 2003, Van de Sande et al., 2005). Here, AKT1 is linked to acute myeloid leukemia.