Regarding the role of MYO1B in cell apoptosis, it promotes apoptosis in senescent cells through ARG2-induced over-activation of MTORC1-RPS6K1 signaling (Yu et al., 2018), whereas it antagonizes apoptosis by preventing nuclear accumulation of PTEN in immortalized cells and tumor cells such as melanoma. The gene discussed is PTEN; the disease is melanoma.