Regarding the role of MYO1B in cell apoptosis, it promotes apoptosis in senescent cells through ARG2-induced over-activation of MTORC1-RPS6K1 signaling (Yu et al., 2018), whereas it antagonizes apoptosis by preventing nuclear accumulation of PTEN in immortalized cells and tumor cells such as melanoma. Here, MYO1B is linked to melanoma.