The impaired Nrf2 nuclear accumulation in renal tubules during AKI to CKD transition was unlikely attributable to an aberrant Keap1-dependent regulation of Nrf2 signaling, because renal expression of oxidized Keap1 was consistently comparable between the low and the high serum creatinine subgroups (Fig. 3D). The gene discussed is KEAP1; the disease is chronic kidney disease.