This antibody specifically recognizes the alternatively-spliced extra-domain A (EDA) of fibronectin, which is expressed at high levels both in inflammatory diseases as well as in numerous cancers.[18, 19] EDA is virtually absent from normal tissues (with the exception of the female reproductive tract), while strongly overexpressed at sites of new blood vessel formation and tissue remodelling.[19, 20]. This evidence concerns the gene FN1 and cancer.