Moreover, inhibition of this axis inhibits tumor growth and angiogenesis.32 Experimental studies showed that animals treated with anti‐SDF‐1 showed higher expression of CXCR7 vs controls, indicating that CXCR7 regulates colon cancer angiogenesis and tumor growth independently of SDF‐1.18 In this study, we investigated angiogenesis through CXCR7 in colon cancer. Here, ACKR3 is linked to malignant colon neoplasm.