In addition, the stimulation of VEGF upregulates the expression of CXCR7 in endothelial cells.29 VEGF affects the germination and proliferation of endothelial cells, consequently stimulating tumor angiogenesis.30 In this experiment, the concentration of VEGF in the silencing group was significantly decreased, whereas that measured in the overexpression group was significantly increased. The gene discussed is ACKR3; the disease is neoplasm.