SLC16A12 is a highly expressed protein in the kidney and has been reported to participate in the transport of creatine.[5,6] Previous researches have demonstrated that the dysregulated expression and mutation of SLC16A12 in gene level are associated with a syndrome combining juvenile cataract with microcornea and renal glucosuria.[7,8] However, no study is currently available focusing on the prognostic value and clinicopathological correlation of SLC16A12 expression in ccRCC. The gene discussed is SLC16A12; the disease is Microcornea.