Obesity is a known contributing factor to increased aldosterone production, and increased adiposity has also been linked to alterations in adrenal function, with increased circulating aldosterone levels.[32] In turn, aldosterone exacerbates glucose intolerance through upregulation of the mineralocorticoid receptor.[33,34] A recent study also show that BMI is an important contributing factor in resolving hypertension following adrenalectomy.[35]. This evidence concerns the gene NR3C2 and obesity due to melanocortin 4 receptor deficiency.