Obesity is recognized as a risk factor for mortality, cardiovascular disease and metabolic disorders, such as hypertension, type 2 diabetes, and dyslipidemia.[29] Many researches showed that obesity increases the chance of hypertension, and insulin sensitivity is significantly associated with hypertension.[30,31] In our series, BMI was also predictive of uncured hypertension. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.