We found that among these genes, ADAM12[14] and BMP5[15] were associated with TGF-β signaling pathway, STEAP3[16] and NEDD9[17] were involved in P53 pathway, Arl4C[18] was associated with Wnt signaling pathway and growth factor-Ras signaling pathway, and GPRC5A[19] is a lung tumor suppressor gene and inhibits the activation of the oncogene EGFR of NSCLC. The gene discussed is GPRC5A; the disease is non-small cell lung carcinoma.