TNF and rheumatoid arthritis: Consistent with our results, a previous study by our team found that after a 6‐month anti‐TNF‐α/DMARDs combination therapy, similar changes in three of the miRNAs found in the present RA cohort significantly increased in response to RTX (miR16‐5p, miR125a‐5p, and miR23a‐3p).13 The up‐regulation of those miRNAs was also associated with the improvement in the disease activity and the reduction in the levels of acute‐phase reactants after therapy.