INS and metabolic syndrome: Other circulating factors previously shown to be unfavorably altered in individuals with MetS include plasma insulin, endothelin‐1, plasminogen activator inhibitor‐1, nitric oxide, C‐reactive protein, and interleukin‐6 (Briançon‐Marjollet et al. 2014; Chedraui et al. 2014; Ahirwar et al. 2015).