PRKAG2 and hypertrophic cardiomyopathy: Among the deleted genes, two genes have cardiac implications: KCNH2, coding for a cardiac potassium channel involved in long QT syndrome (LQTS) (Perrin, Subbiah, Vandenberg, & Hill, 2008); and PRKAG2, associated with hypertrophic cardiomyopathy, cardiac conduction disease, and sudden death (Porto et al., 2016).