Furthermore, 1,25(OH)2D stimulates 24‐hydroxylase activity increasing the catabolism of 25OHD to the inactive compound 24,25(OH)2D, thus increasing the risk of developing vitamin D insufficiency with dietary calcium deficiency.8, 23 Raised PTH levels also lead to renal phosphate loss24 and hypophosphatemia that aggravates the bone mineralization defect. This evidence concerns the gene PTH and hypophosphatemia.