Gla-300 is a new long-acting insulin product delivering the same unit amount of insulin glargine in one-third of the volume compared to Gla-100 and provides even greater glycemic control and hypoglycemia-reducing effects than Gla-100 through better mimicry of the physiological profile of endogenous basal insulin secretion during periods of fasting, between meals, and sleep [7–9]. The gene discussed is INS; the disease is Hypoglycemia.