For that reason, mutations directly to a specific Notch gene (Notch1, Notch2, or Notch3) (Table 1) or in genes codifying for partners of the Notch pathway (FBXW7, Notch ligands, or MAML1) as well as epigenetic modulations of Notch in T-ALL are examined in this paragraph. This evidence concerns the gene NOTCH3 and acute lymphoblastic leukemia.