Genetic alterations in Notch genes, mainly in Notch1 and Notch2, occur in other B-cell malignancies such as CLL, splenic marginal zone lymphoma, mantle cell lymphoma diffuse large B-cell lymphoma (DLBCL) and, rarely, follicular lymphoma [8, 29]. This evidence concerns the gene NOTCH1 and diffuse large B-cell lymphoma.