For that reason, mutations directly to a specific Notch gene (Notch1, Notch2, or Notch3) (Table 1) or in genes codifying for partners of the Notch pathway (FBXW7, Notch ligands, or MAML1) as well as epigenetic modulations of Notch in T-ALL are examined in this paragraph. The gene discussed is MAML1; the disease is acute lymphoblastic leukemia.