IL1A and neoplasm: It is possible that IL-1 signaling is necessary for optimal cetuximab-induced NK cell activity and anti-tumor efficacy which is supported by our data showing that anakinra both suppresses number of activated NK cells induced by cetuximab (Fig. 6) and partially (but significantly) reverses the anti-tumor efficacy of cetuximab in athymic nude mice (Fig. 7) where NK cells are present.