Predictive biomarkers of tumor response to EGFR inhibitors have been well established in non-small cell lung cancer (NSCLC) [8] and colorectal cancer (CRC) [9] but these mechanisms (including EGFR and KRAS mutations) are extremely rare and are not clinically relevant to HNSCC [10, 11]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.