Moreover, endocan levels were greater in patients suffering from systemic manifestations, and they concluded that endocan may impact both endothelial function and the inflammatory process through the pathogenesis of Behçet Disease and attributed the elevated endocan levels found in those patients to the LFA-1/ICAM- 1 pathway inhibition; and stimulation of endocan expression by the raised VEGF plasma levels in Behçet Disease patients (34). This evidence concerns the gene ICAM1 and Behcet disease.