β-Fibrilloses are progressive diseases in relation to the rate of accumulation of β-aggregates and to the severity of specific organ dysfunctions, as it occurs in Alzheimer's or Parkinson's disease, in myocardial amyloidosis by transthyretin and in kidney amyloidosis in the course of primary systemic amyloidosis [13, 23–25]. Here, TTR is linked to primary systemic amyloidosis.