The protective effect of Nrf2 in maintaining the barrier has been proved in various experimental models, including Salmonella typhimurium infection [11], dextran sodium sulfate-induced colitis [11–13], intestinal ischemia-reperfusion [14, 15], aspirin/NSAID-induced vascular damage [16], intestinal burn [17], severe sepsis [18], and traumatic brain injury-induced intestinal mucosa damage and epithelial barrier dysfunction [19] (Table 1). The gene discussed is NFE2L2; the disease is colitis.